Jackson County, Tennessee voted for George McGovern in 1972. It was not an exceptionally Democratic county for Middle Tennessee in 1960 (39.8% of its voters went for Nixon), or, for that matter, 1920, when it went for Harding in one of the most regionally polarized elections in U.S. history. It became one of the most Democratic counties in Tennessee only in the 1964 election as a result of LBJ’s War on Poverty, when Senator Goldwater (who welcomed segregationists into the GOP) only won 19.4% of its vote, and continued to be so even into the election of 2008 (though it had a huge swing to McCain due to Gore voters shaking off his home state effect). It went for the Republican candidate for President for the second time in its history only in 2012, when it had the largest pro-Romney swing of any county in Tennessee. Romney won 57% of the vote -still making that county more pro-Obama than Tennessee as a whole, much less the median county in Tennessee.
In the primary (which was open) Trump got the most votes, followed by Cruz, with Clinton in third place. Bernie got four more votes than Liddle Marco, though he lost to HRC in a landslide.
In the general election, Trump won Jackson County with over 72% of the vote.
“Economic anxiety” is a real thing, folks. The Dems recently lost greater Appalachia because of social and economic issues (guns [from the 1990s], coal [from 2000], abortion [from 1984], same-sex marriage [from 2012], church [from the 1980s]). The Democratic Party being the Black Party was not one of those issues. If the Dems really want to win Appalachia (they don’t), they can get it back via the way of LBJ.